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Psychometric assessment was carried out before starting the current treatment course using the Hamilton Depressive Scale (HAMD-17) and the Hamilton Anxiety Scale (HARS), MMSE was used for cognitive performance assessment

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N-terminal extension : addition of a 13-amino-acid sequence ( Long ) at the N-terminal end, derived from human proinsulin B chain (sequence MFPAMPLSSLFVN-), stabilizing the peptide against aminopeptidases and enhancing solubility

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